Development of mannose-anchored thiolated amphotericin B nanocarriers for treatment of visceral leishmaniasis
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چکیده
منابع مشابه
Development of mannose-anchored thiolated amphotericin B nanocarriers for treatment of visceral leishmaniasis
AIM Our goal was to improve treatment outcomes for visceral leishmaniasis by designing nanocarriers that improve drug biodistribution and half-life. Thus, long-acting mannose-anchored thiolated chitosan amphotericin B nanocarrier complexes (MTC AmB) were developed and characterized. MATERIALS & METHODS A mannose-anchored thiolated chitosan nanocarrier was manufactured and characterized. MTC A...
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Sodium stibogluconate (SSG) in the dose of 20 mg/kg body weight daily intramuscularly for 20-30 days is recommended by WHO as the first line drug for Indian visceral leishmaniasis (VL). Relapses following therapy and unresponsiveness to the higher doses of SSG are still a problem in north Bihar. Serious toxicity of SSG including myocarditis, sudden death and renal failure have also been reporte...
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Visceral leishmaniasis (VL), which is endemic in the Indian subcontinent (42,623 reported cases/year of which 34,918 were in India), the Mediterranian region (875 cases/year), East Africa (8,569 cases/year), and Brazil (3,481 cases/year) has undergone a revolution in chemotherapy in the last 15 years. Treatment had been with the classical agents pentavalent antimony and amphotericin B deoxychol...
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ژورنال
عنوان ژورنال: Nanomedicine
سال: 2017
ISSN: 1743-5889,1748-6963
DOI: 10.2217/nnm-2016-0325